Skin Reboot: Polynucleotides vs. Exosomes – Which Powerhouse Treatment Is Right for You?

Let’s face it — skin isn’t just about what we see. It’s about how we feel, how we glow, and how we age gracefully. And while injectables and skincare serums are still essential players, the real buzz in aesthetics is all about regeneration — going deeper to stimulate your body’s natural power to repair, rebuild, and rejuvenate.

Enter: Polynucleotides and Exosomes — two superstar treatments everyone’s talking about.

But what’s the difference? And which one should you book?

Let’s break it down…

💧 Polynucleotides: The Skin Healer

Imagine giving your skin a gentle nudge to rebuild itself — plumper, firmer, brighter. That’s exactly what polynucleotides do. Derived from purified DNA fragments (often salmon, ultra-refined and completely biocompatible), these little molecules are masters of cell repair.

What They Do:

• Boost collagen & elastin naturally

• Improve skin texture and hydration

• Reduce inflammation, redness & sensitivity

• Revive tired under-eyes, crepey necks, and dull skin

• Stimulate fibroblasts for long-term regeneration

🧬 Think of polynucleotides as biological scaffolding — rebuilding skin structure from within.

Best for:

• First signs of aging

• Sensitive or compromised skin

• Under-eye hollows

• Post-acne scarring

• Skin in need of a “reset”

  
  

⚡ Exosomes: The Cellular Whisperers

Now let’s take it up a notch. Exosomes are tiny extracellular vesicles released by stem cells — packed with growth factors, peptides, and signaling molecules that tell your skin to regenerate faster and smarter.

These are the elite cell communicators. Once delivered into your skin or scalp (usually via microneedling), they get to work rewiring your skin’s recovery systems — often with dramatic results.

What They Do:

• Intensely boost collagen & cellular repair

• Brighten and even out skin tone

• Reduce pigmentation, fine lines & inflammation

• Accelerate healing after peels, lasers, or microneedling

• Wake up hair follicles and support growth

🧪 Think of exosomes as the ultimate multitasker: anti-aging, brightening, healing, and hair-regrowing all in one.

Best for:

• Accelerated aging

• Pigmentation, dullness or uneven skin tone

• Post-procedure recovery

• Hair thinning or scalp issues

• Clients who want fast, visible results

  
  

🔬 So… Which Should You Choose?

Treatment	Polynucleotides 💧	Exosomes ⚡
Source	Salmon-derived Polynucleotides, purified salmon DNA	Stem cells derived/ small vesicles released by stem cells that carry genetic material, proteins to other cells.
Mechanism	Fibroblast stimulation (collagen production)	Cell-to-cell communication (growth factors, miRNA)
Speed of results	Gradual (weeks to months)	Fast (days to weeks)
Best for	Skin bio-revitalization, under-eye rejuvenation	Skin regeneration, hair restoration, post-treatment healing
Primary Benefits	Hydration, collagen remodeling, anti-aging	Anti-aging, skin texture improvement, reduced downtime
Versatility	Mainly skin rejuvenation and elasticity	Skin, hair, post-procedure recovery
Application	Injected, microneedled	Microneedled

Here’s the secret: you don’t have to choose just one. Many clients alternate or combine both for ultimate skin transformation. Polynucleotides rebuild your foundation; exosomes supercharge the result.

Let's dive into downtime...

💧 Polynucleotides

Downtime: Minimal to mild

• Post-injection effects: You may experience slight redness, swelling, or small bumps at the injection points (especially under the eyes), which typically subside within 24–72 hours.

• Microneedling method: If applied via microneedling, expect mild redness or sensitivity for 1–2 days, similar to light sunburn.

• Makeup: Avoid makeup for 24 hours.

• Results: Gradual improvement over 2–6 weeks after each session.

✅ Ideal for people who want natural skin rejuvenation with very little downtime.

⚡ Exosomes

Downtime: Very low, especially compared to more intensive treatments

• When paired with microneedling, exosomes accelerate healing, so redness typically fades within 12–24 hours.

• Less inflammation and flaking than traditional serums or PRP.

• Suitable post-laser or post-peel to shorten recovery time.

• No major visible side effects unless paired with a more invasive procedure.

✅ Perfect for clients wanting fast recovery and a visible glow with minimal disruption.

Here’s a glimpse at my client’s glow-up — from their very first exosomes session to 3 weeks in, just before round two!

Something tells me it’s only the beginning…😚

✨ Ready to Glow Like Never Before?

Whether you're dreaming of firmer skin, a fresher under-eye, or just a subtle-yet-powerful lift without volume or downtime — regenerative aesthetics is the future.

These aren’t just treatments. They’re investments in your skin’s health.

Let’s make your skin feel stronger, fresher, and more radiant than ever. 💫

With warmth and love ❤️

Wioleta